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Immune Response Validation Can Be a Life Saver!

Immune Response Validation Can Be a Life Saver!

Recently, a veterinarian from a large clinic contacted me as he suspected Parvo disease in “Tommy”, a five month old mixed breed dog.

Tommy was adopted a few months ago from a shelter and since then he has begun receiving all three-core vaccines – Canine Parvo Virus (CPV), Canine Distemper Virus (CDV) and Canine Adeno Virus (CAV), according to the recommended protocol (which is from the age of 8 weeks, at 3 week intervals).

About a week after receiving his last vaccine injection, Tommy began to show suspicious signs of Parvo – loss of appetite, lethargy and watery diarrhea. A blood count test showed no Parvo signs. Tommy was hospitalized because of his poor condition, and still the suspicion for Parvo.1st Titer Test Result

We ran Tommy’s blood sample using VacciCheck in order to get the full picture of his immune status and response to the vaccines. We realized Tommy’s immune system responded well to the distemper vaccine and to the Adenovirus vaccine components. However, and amazingly so, no response to the Parvo virus component was seen.

A possible reason for not responding to the vaccine, may be genetically based; Non-Responders who cannot respond specifically to one of the vaccine components (1: 1000 for Parvo, 1: 5000 for Distemper, and 1: 100,000 for Adenovirus). Potential additional reasons may be the presence of maternal antibodies that interfere with the vaccine (which is not common at the age of 5 months), or any other cause like improper vaccine manufacturing or storage which can lead to a non-response to the vaccine.

Two days after being hospitalized, Tommy’s blood count tests showed clear signs of Parvo (↓↓↓Whole Blood Count).

2nd Titer Test Result

We are glad to note that Tommy recovered. Sufficient Parvo antibodies were found by using VacciCheck, showing the unlikelihood that Tommy is a genetic Non-Responder.

Parvo is a very contagious disease, with high morbidity and mortality rates. The disease breaks out very quickly by attacking dividing cells, such as the cells of the intestine, causing severe diarrhea and bone marrow cells, which aggravate the condition due to secondary infections.

Untreated dogs could die within 2 days after signs of illness appear. The survival percentage in treated dogs is 68% – 92%.

My take home message: in order to be sure that your beloved puppies are protected from this severe disease, it is possible to verify protection by a simple examination, and so avoiding unnecessary suffering and long and expensive hospitalization.